Journal article
Cationic acrylate oligomers comprising amino acid mimic moieties demonstrate improved antibacterial killing efficiency
JL Grace, AG Elliott, JX Huang, EK Schneider, NP Truong, MA Cooper, J Li, TP Davis, JF Quinn, T Velkov, MR Whittaker
Journal of Materials Chemistry B | ROYAL SOC CHEMISTRY | Published : 2017
DOI: 10.1039/c6tb02787c
Abstract
Cu(0)-mediated polymerization was employed to synthesize a library of structurally varied cationic polymers and their application as antibacterial peptide mimics was assessed. Eight platform polymers were first synthesized with low degrees of polymerization (DP) using (2-Boc-amino)ethyl acrylate as the monomer and either ethyl α-bromoisobutyrate or dodecyl 2-bromoisobutyrate as the initiator (thus providing hydrocarbon chain termini of C2 or C12, respectively). A two-step modification strategy was then employed to generate the final sixteen-member polymer library. Specifically, an initial deprotection was employed to reveal the primary amine cationic polymers, followed by guanylation. The bi..
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Awarded by National Institutes of Health
Funding Acknowledgements
This collaborative research was conducted by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). JLG wishes to acknowledge receiving an APA scholarship. TPD wishes to acknowledge the award of an Australian Laureate Fellowship. Jian Li and Tony Velkov are supported by a research grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (RO1 AI111965). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health. Jian Li is an Australian NHMRC Senior Research Fellow. Tony Velkov is an Australian NHMRC Industry Career Development Research Fellow. Matthew Cooper would like to acknowledge a grant from the NHMRC PRF APP 1059354 (2014-2018). JLG would like to acknowledge Dr Jeroen Goos (ARC CoE CBNS, Monash University) for the kind gift of 2-(Bocamino) ethyl acrylate.